The definitive journal for scientists, clinicians, and trainees in the field of oncology worldwide - now complementary for JAMA subscribers! Clinical Challenges Dermatology Infectious Disease Neurology Oncology Ophthalmology Otolaryngology Pediatrics Radiology Surgery View All Specialties JN Listen Promo Offer About App Store Buy Now Subscriptions Learn More About CME / MOC Apps JAMA Network This Viewpoint advocates for a reevaluation of the use of temozolomide for patients with MGMT p unmethylated glioblastomas during the COVID-19 pandemic. This Viewpoint explores the application of the results of the ADAURA trial. Clinical trials, our best tool to improve cancer treatment for patients through testing the clinical value of a new treatment, have been affected by the pandemic. However, they present some ethical concerns referred to scientific validity, risk-benefit balance and informed consent. Browse the full JN Learning collection of over 140 Otolaryngology CME activities. CLINICAL CHALLENGE 1 Credit CME Split Down the Middle of the Fovea JAMA Ophthalmology. Despite the lack of randomized clinical studies, hemoglobin transfusions are widely believed to mitigate tumor hypoxia-associated radiotherapy resistance, a significant clinical challenge for … Krista.Stewart: Created page with "{{Article |Authors=Krista.Stewart, Victoria Sattarova |Category=Oculoplastics/Orbit |Date reviewed=June 15, 2021 }} Article summary goes here. CLINICAL CHALLENGE 1 Credit CME Facial Numbness, Dysarthria, Muscle Atrophy, and Weakness in a Young Patient JAMA Neurology. Image Challenge. Van Allen EM(1)(2)(3). Take the activities on JN Learning to receive more than 140 CME Credits. JAMA Oncology Clinical Challenge Pancytopenia in a Patient With Metastatic Well-Differentiated Neuroendocrine Tumor After Peptide Receptor Radionuclide Therapy Satya Das, MD, MSCI; Jordan Berlin, MD; Michael Savona, MD Saif Ahmad our Podcast Editor brings you in-depth interviews with selected authors of papers published in recent editions of Clinical Oncology. Take the activities on JN Learning to receive more than 250 CME Credits. ... JAMA Oncology (80) JAMA Cardiology (67) JAMA Pediatrics (60) JAMA Neurology (43) JAMA Psychiatry (6) Article Type All Article Types. Can you correctly diagnose and treat unusual presentations of epilepsy and seizures, cerebrovascular disease, neurodegenerative disease, CNS infections, vasculitis, and more? JAMA editors and authors explore innovations and ideas in medical research and clinical practice. 1 Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York. Design, setting, and participants: A cluster randomized clinical trial of the Serious Illness Care Program in an outpatient oncology setting was conducted. Clinical trials, our best tool to improve cancer treatment for patients through testing the clinical value of a new treatment, have been affected by the pandemic. Clinical Challenges in Oncology Can you correctly diagnose and treat unusual presentations of acute myeloid leukemia, skin and Burkitt lymphoma, lung cancer, and more? Can you correctly diagnose and treat cases of dysphagia, vestibular dysfunction, vasculitis, and more? online first. The U.S. Food and Drug Administration is issuing warning letters to firms for selling fraudulent products with claims to prevent,... Search ALLMEDX Now! Clinical Challenges in Dermatology. The traditional approach to drug development in oncology, with discrete phases of clinical testing, is becoming untenable owing to expansion of the … Jack Khouri, MD; et al. Browse the full JN Learning collection of over 250 Ophthalmology CME activities. Since 2015, the US Food and Drug Administration (FDA) has granted 35 accelerated approvals to programmed cell death 1 (PD-1) and/or PD-1 ligand 1 (PD-L1) inhibitors, or just under half of the total (76) approvals for this class of medications. Saif Ahmad our Podcast Editor brings you in-depth interviews with selected authors of papers published in recent editions of Clinical Oncology. The American Society of Clinical Oncology (ASCO) is a professional organization representing physicians of all oncology sub-specialties who care for people with cancer.Founded in 1964 by Fred Ansfield, Harry Bisel, Herman Freckman, Arnoldus Goudsmit, Robert Talley, William Wilson, and Jane C. Wright, it has nearly 45,000 members worldwide. Author information: (1)Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. The COVID-19 pandemic affected millions of people globally with lasting effects on society, patients, investigators and health institutions. Clinical oncology is experiencing rapid growth in data that are collected to enhance cancer care. Listen to JAMA Oncology : Neuronal Autoantibodies And Cognitive Impairment In Patients With Lung Cancer and 199 more episodes by JAMA Network, free! Main focuses of interest include:... Annals of Oncology, the journal of the European Society for Medical Oncology and the Japanese Society of Medical Oncology, provides rapid and efficient peer-review publications on innovative cancer treatments or translational work related to oncology … JAMA Cardiology : Posttraumatic Stress Disorder and Cardiovascular Disease. No signup or install needed. JAMA editors and authors explain the methods underlying clinical research to help health professionals use medical literature to make evidence-based decisions. Hear authors from the current issue of JAMA Cardiology discuss their ideas and findings. Hear authors from the current issue of JAMA Dermatology discuss their ideas and findings. Browse the full JN Learning collection of over 250 Ophthalmology CME activities. Inequitable access to clinical trials disadvantages many underrepresented groups, prolongs recruitment and potentially increases trial costs. The journal's original, innovative, and timely scientific and educational content provides a deeper understanding of cancer pathogenesis and recent treatment advances for readers. Can you correctly diagnose and treat unusual presentations of skin cancer, atopic dermatitis, psoriasis, skin lymphomas, cutaneous drug reactions, and more? Novel precision oncology trial designs, such as basket and umbrella trials, are designed to test new anticancer agents in more effective and affordable ways. Browse the full JN Learning collection of over 250 Neurology CME activities. The American Society of Clinical Oncology (ASCO) National Oncology Census defines who the U.S. oncology community is, and their perceptions of how practice patterns may be changing. To the Editor.— I read the editorial by Drs. 2017 Sep 5;318(9):801-803. doi: 10.1001/jama.2017.11022. JAMA Clinical Reviews. Patients with advanced cancer (n = 278) and oncology clinicians (n = 91) participated between September 1, 2012, and June 30, 2016. A 19-year-old man presented with 4 years of facial numbness, 3 years of progressive dysarthria and dysphagia, 18 months of arm weakness and hand atrophy, and 6 months of leg weakness. JAMA Oncology Clinical Challenge Pancytopenia in a Patient With Metastatic Well-Differentiated Neuroendocrine Tumor After Peptide Receptor Radionuclide Therapy Satya Das, MD, MSCI; Jordan Berlin, MD; Michael Savona, MD Case Report. Can you correctly diagnose and treat cases of blurry vision, visual impairment, edema, headaches, and more? Coverage from the meeting, which brought together health care professionals involved in the research and management of … 2016;2(6):815-816. Discussions of how clinicians should address challenges of adverse events in their practices. Browse the full JN Learning collection of over 200 Dermatology CME activities. Take the activities on JN Learning to receive more than 200 CME Credits. Browse the full JN Learning collection of over 200 Dermatology CME activities. It aims to effectively convey the findings of important clinical research, major scientific breakthroughs, actionable discoveries, and state-of-the-art treatment pathways to the oncology community. The first bottleneck for studies is recruitment, which represents the single largest cost-driver for clinical trials and accounts for 30% of failures in phase III studies. JAMA Oncology : Neuronal Autoantibodies and Cognitive Impairment in Patients With Lung Cancer. Clinical Challenges in Ophthalmology. Take the activities on JN Learning to receive more than 250 CME Credits. Van Allen EM(1)(2)(3). Crafting a JAMA Oncology Clinical Challenge. JAMA. 2017 Sep 5;318(9):801-803. doi: 10.1001/jama.2017.11022. Novel precision oncology trial designs, such as basket and umbrella trials, are designed to test new anticancer agents in more effective and affordable ways. Identify all potential conflicts of interest that might be relevant to your comment. Physical exam showed tachypnea and marked hepatomegaly, as well as small hemangiomas on the skin. CLINICAL CHALLENGE 1 Credit CME Facial Numbness, Dysarthria, Muscle Atrophy, and Weakness in a Young Patient JAMA Neurology. Browse the full JN Learning collection of over 140 Otolaryngology CME activities. Inequitable access to clinical trials disadvantages many underrepresented groups, prolongs recruitment and potentially increases trial costs. JAMA Oncology : Neuronal Autoantibodies and Cognitive Impairment in Patients With Lung Cancer. No signup or install needed. 2 Fred Hutchinson Cancer Research Center, University of … The American Cough Conference was held June 11-12. Monica Morrow, MD 1; Mary L. Disis, MD 2. A show about ideas and innovations in medicine, science, and clinical practice. Join Howard Bauchner, MD, each week as he interviews leading researchers and thinkers in health care about their recent JAMA articles. Discussions of timely topics in clinical medicine, biomedical sciences, public health, and health policy. Clinical Challenges in Neurology. Lower Back Pain in a Patient With Sarcoma. 1 Of the 35 approvals, 10 were considered “dangling,” with postmarketing trials failing to meet key end points to confirm benefit for patients. CLINICAL CHALLENGE 1 Credit CME Nodular Mass in the Earlobe of 18-Month-Old Girl JAMA Otolaryngology–Head & Neck Surgery. Patients with advanced cancer (n = 278) and oncology clinicians (n = 91) participated between September 1, 2012, and June 30, 2016. Can you make the diagnosis and order the next best test or treatment? Sebastian Mönch, MD; et al. An umbrella trial enrolls patients with one cancer type but with different genetic changes within each tumor (Fig. 1 ). It consists of many small sub-trials to test multiple drugs simultaneously in one large trial [ 2, 6 ]. Patients receive different targeting treatments matched to their genetic aberration. Ge n e r a l Aringer M, Burkhardt H, Burmester GR, Fischer-Betz R, Fleck M, et al. The traditional approach to drug development in oncology, with discrete phases of clinical testing, is becoming untenable owing to expansion of the … A 16-day-old girl was brought to the emergency department with lethargy. CLINICAL CHALLENGE 1 Credit CME Split Down the Middle of the Fovea JAMA Ophthalmology. Is quite a step back and highly impractical consists of many small sub-trials to test multiple simultaneously... 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