oil in water emulsion bases. An Example: Excipient CMA Identification and Control •22 factorial design is used to investigate the effect of acid value variation for two excipients (cetyl ester wax and glyceryl monostearate) used in a cream formulation on chemical stability of a drug • % impurity A detected for stability samples stored at 40°C/75% RH for six months as the It is also used as a thickening and emulsifying agent. For example, vitamin A creams and bleaching creams can make your skin more sensitive to the sun, increasing the ease at which you burn. 1. Understanding the chemical basis of drug stability and degradation. 33 Describe the fi ve types of drug instability of concern to the practicing ... administration sites (ointments, creams, trans-dermal patches, and ophthalmic, ear, and nasal preparations) ... a Pharmaceutical Company to meet the special requirements of the patient. Generally speaking, there are 3 types of pharmaceutical packaging which is used by drug manufacturers for all sorts of pharmaceutical products ranging from pills to capsules. An Example: Excipient CMA Identification and Control •22 factorial design is used to investigate the effect of acid value variation for two excipients (cetyl ester wax and glyceryl monostearate) used in a cream formulation on chemical stability of a drug • % impurity A detected for stability samples stored at 40°C/75% RH for six months as the 3, ed. Creams may be considered pharmaceutical products as even cosmetic creams are based on techniques developed by pharmacy and unmedicated creams are highly used in a variety of skin conditions (dermatoses). Sample from Introduction to Pharmaceutical Calculations, 4th edition, published by Pharmaceutical Press Trim size: 156mm x 234mm IPC c04.tex V1 - 03/05/2015 9:59 P.M. Express this as a ratio strength. Melting range :- 38 to 56°c II. For example, 10 mL of alcohol dissolved in a sufficient quantity of water to make 40 mL of solution is dimensionless: 10 mL/40 mL= 0.250 (or 25% v/v). Antibiotics – Neosporin and Polysporin are popular topical antibiotics that come in both a cream and ointment form. In this science article, Timothy J. Snape, Alison M. Astles and Janice Davies discuss the chemical basis for the stability of certain functional groups within drug molecules against hydrolytic degradation and consider the methods used to maximise their stability on storage. • Carbon black and talc are preferentially wetted by oil and thus stabilize w/o emulsions. Easy to wash. 2. topical, oral or parenteral. To request samples, please visit almirallsamples.com. But this free medical PowerPoint template is the perfect mix of professionalism and a fun, engaging design. ... formulated as creams, lotions or ointments mean that adequate microcidal efficacy may not be attainable. Two samples of each of the seven, easily emulsifiable creams, were challenged with standard strains of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans to assess the efficacy of the preservatives used in their preparations. Benzophenone, hydroquinone. • The aim of Pharmaceutical Development is to design a quality – Product – Manufacturing Process • to consistently deliver the intended performance of the product • Provides scientific understanding to support the establishment of – Design Space – Specifications – Manufacturing Controls Design Space: The multidimensional combination and interaction of ... Journal of Pharmaceutical Science and Bioscientific Research, 5(5), 520-528. Pharmaceutical applications are classified according to the route of administration i.e. Order the samples you need and electronically sign or print and fax back You can also call the PfizerPro Customer Service Center at 1-800-505-4426 to place a request. • Petroleum (soft paraffin) :- Semi solid hydrocarbon + lubricating oil I. Yellow soft paraffin :- obtained from petroleum also may contain anti oxidant like vit.E and BHT. Dermatological Creams and Lotions: Creams and lotions are used topically to the affected area only. Water soluble bases like as macrogols 200, 300, 400. dosage strength : Amount of active drug contained in a particular formulation; for example 50, 100, or 500 milligrams. SHAYNE COX GAD, PhD, DABT, ATS, is the Principal of Gad Consulting Services. Topical emollients can be used on a daily basis to improve skin hydration in people prone to dry skin. Eccleston GM (2007). classified as oil in water (o/w) or water in oil (w/o) emulsions. Comparatively, o/w emulsions do not have the limitation of hydrophilic balance so confer a wider selection of emulsifiers. ... Journal of Pharmaceutical Science and Bioscientific Research, 5(5), 520-528. For example, pain killers like diclofenac is available as tablet, injection and even ointment. Correct pharmaceutical calculations can be accomplished by using, for example, proper conversions from one measurement system to another and properly placed decimal points, by understanding the arithmetical concepts, and by paying close attention to the details of the calculations. BRIEF HISTORY A modern version, consisting of almond oil, spermaceti, white wax, and rose water, passed into the United States Pharmacopeia as ‘‘Rose Water Ointment’’ or ‘‘Galen’s Cerate.’’. Pharmaceutical creams and ointments are semi-solid emulsions of … Humectant. Examples of Creams. Preservatives Used in Pharmaceutical Industry. Drugs are given in different forms. Generally, ointments and w/o creams are less irritating, while gels are irritating. Ideal moisturizing formula for dry skin associated with atopic dermatitis (eczema), psoriasis, and winter itch. Ideal formulation. myoldmeds.com. There are 4 main ointment bases: Hydrocarbon bases, e.g. Fruit extracts. aminophylline 250mg/250ml D5W dobutamine 250mg/250ml D5W dopamine 400mg/250ml D5W heparin 25,000 units/500ml D5W insulin 25 units/250ml NS lidocaine 2g/500ml D5W magnesium 40g/500ml D5W nitroglycerin 50mg/250ml D5W (glass bottle) nitroprusside 50mg/250ml D5W (wrap) oxytocin 30 units/1000ml Triamcinolone acetonide dental paste (Kenalog in Orabase) is one example using Orabase to deliver a corticosteroid to oral tissues for temporary relief of symptoms associated with oral inflammatory lesions and ulcerative lesions resulting from trauma. Pharmaceutical Compounding and Dispensing focuses on what pharmacy students really need to know in order to pass exams, providing concise, bulleted information, key points, tips and an all-important self-assessment section which includes MCQs, case studies, sample essay questions and worked examples. 203, 127-139. PHM4153 Dosage Design 2 2011/12. As you notice, the cosmetic industry is booming with all its beauty and skin products because humanity has gotten far concerned with health and beauty more than any other material things. 4. Process whereby drugs are combined with other substances (excipients) e.g. preservative to produce dosage forms e.g. cream suitable for administration to or by patients. Every medicinal product is a combination of the drug substance and excipients. Informa Healthcare, Inc., New York. Creams may be considered pharmaceutical products as even cosmetic creams are based on techniques developed by pharmacy and unmedicated creams are highly used in a variety of skin conditions (dermatoses). Examples include ointments, pastes, creams, gels etc. For example, avoid greasy ointments for acute weepy dermatitis. The best new therapeutic entity in the world is of little value without an appropriate delivery system. Like pharmaceutical manufacturers, manufacturers of personal care products like cosmetics, perfumes, creams and lotions generate waste that requires specialized disposal. Triethanolamine soaps, formed in situ by the partial neutralization of fatty acid (generally stearic acid) by TEA have a long history of use in the formulation of cosmetic and pharmaceutical o/w vanishing creams. 300,000-1,000,000 ointments. This pharmaceutical PowerPoint template exploits this feature to make an outstanding presentation. Start studying Pharmaceutical Ingredients (Definitions & Examples). Types of excipients. Normally, photostability testing is carried out on a single batch. Pharmaceutical cream may be easily spreadable than the ointment. Explanation . They are those medications purchased over the counter, the majority of which are bought without a prescription. Dr. Gad has more than thirty years of experience as a toxicologist, statistical consultant, manager, and general consultant on research and development in the chemical, consumer product, contract testing, biotechnology, medical device, and pharmaceutical industries. Example: diblock polymer polylactic acid – polyethylene glycol (PLA- High-density polyethylene is a material which is mostly used by pharmaceutical industry for containers for drugs. Compounding type . J. Pharm. A same drug is made in different forms for ease of administration, pharmacology and patient related factors. Synchrotron X-ray investigations into the lamellar gel phase formed in pharmaceutical creams prepared with cetrimide and fatty alcohols. 8. Whitening. ... Let’s discuss some specific examples of pharmaceutical waste. Introduction A number of drugs that possess a variety of pharmacological activities (e.g. emulsion of water and oil. Start studying Pharmaceutical Dispersions II: Gels and Aerosols. Properties. Sorbitan stearate, lecithin, lanolin/lanolin alcohols, and glyceryl monooleate are some examples of viable w/o emulsifiers. Examples include ointments, pastes, creams, gels etc. search sequence. Definition: A gel is a solid or semisolid system of at least two constituents, consisting of a condensed mass enclosing and interpenetrated by a liquid4. anti-inflamma- tory, antimycotic) are currently used as creams … Cream base contain large amounts of water so that can increase the release of the drug. Many people are afraid that using transitions and animations will make them look unprofessional and not take them seriously. The heart of our Samples Center of Excellence is a PDMA-savvy, samples-only team and technology dedicated to meeting the distinct requirements of pharma sample program management. z 7 d d t Ct SC ompetence Standard 7 (P Ph ti l (Prepare Pharmaceutical Products - Non Sterile) covers the preparation of pharmaceutical products in hospital and community phiharmacies zThe pharmacist prepares small quantities of extemporaneously compoundedproducts such as creams, suspensions and suppositories (i.e. The intrinsic photostability characteristics of new drug substances and products should be evaluated to demonstrate that, as appropriate, light exposure does not result in unacceptable change. There are some advantages of cream preparations: 1. On the other hand, Pharmaceutical ointments may be less spreadable on the skin than cream and make an occlusive layer on the skin. 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